A Case Report of a Poor Metabolizer of CYP2D6 Presented with Unusual Responses to Nortriptyline Medication

نویسندگان

  • Soo-Youn Lee
  • Chang-Seok Ki
  • Kyung Sue Hong
  • Jong Won Kim
چکیده

We present a case with decreased metabolic activity of CYP2D6, a cytochrome P450 enzyme catalyzing the metabolism of nortriptyline (NT). Conventional dosage regimen led to toxic plasma concentration of NT and adverse effects such as dry mouth, constipation, and dizziness in this case with genotype CYP2D6*5/*10B. This case suggests the clinical usefulness of pharmacogenetic testing in individualized dosage adjustments of NT.

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عنوان ژورنال:

دوره 19  شماره 

صفحات  -

تاریخ انتشار 2004